Title: PKCα Attenuates Jagged-1-mediated Notch Signaling in ErbB-2 positive Breast Cancer to Reverse Trastuzumab Resistance Authors/Affiliations:
نویسندگان
چکیده
Molecular Biology Program, Oncology Research Institute, Department of Molecular Pharmacology and Therapeutics, Integrated Cell Biology Program, Louisiana State University, New Orleans, LA, Department of Histopathology, University of Nottingham and University Hospital NHS Trust, Nottingham, United Kingdom, Emperial College of London, London, United Kingdom, CytomX Therapeutics, Department of Medicine/Hematology and Oncology, Department of Pathology, Department of Microbiology and Immunology. Cardinal Bernardin Cancer of Loyola University Chicago: Health Sciences Division, Maywood, IL, 60153.
منابع مشابه
PKCα Attenuates Jagged-1-Mediated Notch Signaling in ErbB-2-Positive Breast Cancer to Reverse Trastuzumab Resistance.
PURPOSE Breast cancer is the second leading cause of cancer mortality among women worldwide. The major problem with current treatments is tumor resistance, recurrence, and disease progression. ErbB-2-positive breast tumors are aggressive and frequently become resistant to trastuzumab or lapatinib. We showed previously that Notch-1 is required for trastuzumab resistance in ErbB-2-positive breast...
متن کاملPKCα Attenuates Jagged-1-mediated Notch Signaling in ErbB-2 positive Breast Cancer to Reverse Trastuzumab Resistance Authors/Affiliations:
Molecular Biology Program, Oncology Research Institute, Department of Molecular Pharmacology and Therapeutics, Integrated Cell Biology Program, Louisiana State University, New Orleans, LA, Department of Histopathology, University of Nottingham and University Hospital NHS Trust, Nottingham, United Kingdom, Emperial College of London, London, United Kingdom, CytomX Therapeutics, Department of Med...
متن کاملBiology of Human Tumors PKCa Attenuates Jagged-1–Mediated Notch Signaling in ErbB-2–Positive Breast Cancer to Reverse Trastuzumab Resistance
Purpose: Breast cancer is the second leading cause of cancer mortality among women worldwide. The major problem with current treatments is tumor resistance, recurrence, and disease progression. ErbB-2–positive breast tumors are aggressive and frequently become resistant to trastuzumab or lapatinib. We showed previously that Notch-1 is required for trastuzumab resistance in ErbB-2–positive breas...
متن کاملPKCa Attenuates Jagged-1–Mediated Notch Signaling in ErbB-2–Positive Breast Cancer to Reverse Trastuzumab Resistance
Purpose: Breast cancer is the second leading cause of cancer mortality among women worldwide. The major problem with current treatments is tumor resistance, recurrence, and disease progression. ErbB-2–positive breast tumors are aggressive and frequently become resistant to trastuzumab or lapatinib. We showed previously that Notch-1 is required for trastuzumab resistance in ErbB-2–positive breas...
متن کاملTrastuzumab Resistance: Role for Notch Signaling
Epidermal growth factor receptor-2 (ErbB-2/HER2) is a potent breast oncogene that has been shown to be amplified in 20% of breast cancers. Overexpression of ErbB-2 predicts for aggressive tumor behavior, resistance to some cytotoxic and antihormonal therapies, and poor overall survival. Trastuzumab, the humanized, monoclonal antibody directed against ErbB-2 has shown tremendous efficacy and imp...
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